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PostPosted: Fri Sep 17, 2010 12:16 pm 
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Joined: Mon Feb 07, 2005 6:39 pm
Posts: 2987
Location: Toronto
September 16, 2010

Subject: ACTEMRA™ (tocilizumab) and the Risk of Death Due to Severe Allergic Reaction

Hoffmann-La Roche Limited, in consultation with Health Canada, has informed health care professionals of important new safety information regarding ACTEMRA™ (tocilizumab) and severe allergic reactions.

ACTEMRA is a drug that is used intravenously to treat adults with moderate to severe rheumatoid arthritis.

Roche would like to inform you of the following;

* A death from a severe allergic reaction has been reported in a patient with rheumatoid arthritis treated with ACTEMRA. No Canadian cases of anaphylactic reaction have been reported.
* As allergic reactions can occur with the administration of ACTEMRA, it is important that you are monitored closely throughout the infusion for signs and symptoms of any allergic reaction.
* ACTEMRA should not be given to patients who are allergic to tocilizumab or any non-medicinal ingredient in ACTEMRA.

Gwen notes: this was in an elderly patient, who had blood pressure issues. Rest of advisory is here: ... cp-eng.php

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